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Research

Rosiglitazone and Insulin in T1DM Adolescents

8 Jul 2007
Type 1 Diabetes is the most common life-long disorder with onset in childhood. Patients need insulin injections, blood sugar monitoring several times each day, and adhere to a strict diet. Adequate ... › More

Comparison of Insulin Detemir With NPH Insulin in Type 1 Diabetes

22 Jun 2007
The aim of this research study is to compare the efficacy (reduction in HbA1c and in blood glucose levels) of insulin detemir compared to NPH insulin administered as basal insulin for the treatment ... › More

SMOOTH - Blood Pressure Control in Diabetic/Obese Patients

20 Jun 2007
The primary objective of the SMOOTH study was to demonstrate that, when combined with hydrochlorothiazide (12.5 mg), telmisartan (80 mg) is at least as effective and possibly superior to valsartan ... › More

Study Evaluating the Safety and Efficacy of ERB-041 on Reduction of Symptoms Associated With Endometriosis in Reproductive-Aged Women

12 Jun 2007
The purpose of the study is to evaluate the efficacy and safety of two doses of ERB-041 (75 mg and 150 mg) relative to placebo on the relief of endometriosis-related symptoms (dysmenorrhea, pelvic ... › More

GALLANT 22 Tesaglitazar Vs. Placebo in Patients with Type 2 Diabetes

17 May 2007
This is a 24-week randomized, double-blind, parallel-group, multi-center, placebo-controlled study of tesaglitazar (0.5 and 1 mg) in patients with type 2 diabetes, not adequately controlled on diet ... › More

Thyroid-Associated Ophthalmopathy Subtypes and Orbital Antibodies in patients with hyperthyroidism due to Graves' disease

10 Apr 2007
The purpose of this study is to determine whether radioactive iodine, as compared to anti-thyroid medications, is a risk factor for the development or progression of thyroid-associated ophthalmopathy ... › More

Blood Pressure and Glucose Lowering for the Prevention of Vascular Disease in High Risk Patients With Type 2 Diabetes.

2 Apr 2007
The purpose of this study is to provide information on the risks and benefits of routine blood pressure lowering (regardless of blood pressure level), and intensive lowering of blood glucose levels, ... › More

Lanreotide Autogel in Patients With Acromegaly Previously Treated With Octreotide LAR

28 Mar 2007
The purpose of this study is to assess the efficacy, safety and patient acceptability of Somatuline Autogel in patients with acromegaly previously treated with octreotide LAR. › More

Saxagliptin Treatment in Subjects With Type 2 Diabetes Who Are Not Controlled With Diet and Exercise

9 Mar 2007
The purpose of this clinical research study is to learn whether Saxagliptin is more effective than placebo as a treatment for type 2 diabetic subjects who are not sufficiently controlled with diet ... › More

A Study to Investigate the Effect of Rosuvastatin (CRESTOR) on High Density Lipoprotein Kinetics in Patients With the Metabolic Syndrome

17 Feb 2007
The purpose of this study is to investigate the dose-related effect of treatment with rosuvastatin on production and fractional catabolism of apolipoprotein A-I (apoA-I) and apolipoprotein A-II ... › More

Trials

FIELD -Fenofibrate Intervention and Event Lowering in Diabetes

12 Nov 2007
The FIELD trial "Fenofibrate Intervention and Event Lowering in Diabetes" aims to determine whether treatment with fenofibrate, a potent modifier of blood lipid levels, will reduce the risk of fatal ... › More

Ezetimibe/Simvastatin in Patients With Metabolic Syndrome

5 Nov 2007
A 6-week clinical trial in patients with metabolic syndrome and hypercholesterolemia at high risk for coronary heart disease to study the effects of ezetimibe/simvastatin and atorvastatin on lipids. › More

Goserelin in Preventing Ovarian Failure in Women Receiving Chemotherapy for Breast Cancer

3 Aug 2007
Goserelin blocks hormone production in the ovaries. It is not yet known whether ovarian suppression using goserelin will prevent ovarian failure (early menopause) in women receiving chemotherapy for ... › More

Comparison of Two Basal Insulin Therapies for Patients With Type 1 Diabetes (IOOZ)

17 Jul 2007
The purpose of this study is to examine the effectiveness and safety of lispro protamine suspension as compared to insulin detemir as basal plus mealtime insulin therapy in patients with type 1 ... › More

E.V.O.L.V.E. Trial: EValuation Of Cinacalcet HCl Therapy to Lower CardioVascular Events

5 Jul 2007
This study will evaluate the effects of cinacalcet (cincalcet HCl or Sensipar/Mimpara) on cardiovascular events and death in chronic kidney disease (CKD) patients with secondary hyperparathryoidism ... › More

Comparison of Two Approaches to Insulin Therapy in Patients With Type 2 Diabetes

30 Jun 2007
A study of patients with type 2 diabetes who are not controlled on two or more oral antihyperglycemic agents comparing adding insulin lispro mid mixture to the oral antihyperglycemic agents to adding ... › More

Predictive Markers in GHD and TS Children Treated With 'SAIZEN'

23 Jun 2007
The study aims at identifying the predictive markers after one month of Saizen therapy in Growth Hormone Deficiency (GHD) and Turner Syndrome children. The study will recruit approximately 360 ... › More

The DURABLE Trial: Evaluating the Durability of Starter Insulin Regimens in Patients With Type 2 Diabetes

7 Jun 2007
This study will compare insulin lispro low mixture [LM] and insulin glargine in combination with the patient's oral diabetes medicines for their ability to control blood sugar in patients with type 2 ... › More

Sympathetic Activity in Individuals With the Metabolic Syndrome: Benefits of Lifestyle Interventions

31 May 2007
An abdominal distribution of fat is associated with the greatest heart disease risk, because commonly, several risk factors of metabolic origin (high blood pressure, unfavourable cholesterol profile, ... › More

Study Evaluating the Safety and Efficacy of a Once-Daily Dose of Tigecycline vs Ertapenem in Diabetic Foot Infections with Osteomyelitus

31 May 2007
This purpose of this study is to look at the safety and effectiveness of a once-daily dose of tigecycline compared to ertapenem for the treatment of diabetic foot infections with osteomyelitis. › More

The support of the following commercial entities are greatfully acknowledged: